WEEK12: 49ERS VS. PANTHERS
đź—“ Date & Kickoff Time:
Monday, November 24, 2025, at 8:15 PM ET
đź“Ť Location:
Levi’s Stadium, Santa Clara, California
đź“ş TV & Streaming Options:
-
National broadcast on ESPN (with full Monday Night Football theme)
Stream available on NFL+, YouTube TV, Hulu Live, or the ESPN App
🎟 How to Get Tickets & Price Range:
-
Tickets available on Ticketmaster, SeatGeek, and NFL Ticket Exchange
Prices range from $79 to $350+, depending on seat location and time of purchase
📉 BETTING ODDS & SPREAD
-
Point Spread: 49ers -7
Over/Under: 49.5 points
Moneyline: 49ers -350 | Panthers +280
The Panthers enter as underdogs but have gone 6-4 outright and 7-3 ATS when underdogs this season.
đź©ş FINAL INJURY REPORT (as of Nov. 23)
🔹 Carolina Panthers (7 players)
| Player | Position | Injury | Practice Status |
|---|---|---|---|
| Bryce Young | QB | Ankle | Full Participation |
| Xavier Legette | WR | Hip | Full Participation |
| Tetairoa McMillan | WR | Ankle | Full Participation |
| Lathan Ransom | S | Hand | Full Participation |
| Tershawn Wharton | DT | Knee | Limited Participation |
| Trevin Wallace | LB | Shoulder | Did Not Practice |
| Christian Rozeboom | LB | Hip | Did Not Practice |
Panthers could be without both starting inside linebackers.
🔺 San Francisco 49ers (10 players)
| Player | Position | Injury | Practice Status |
|---|---|---|---|
| Brock Purdy | QB | Toe | Full Participation |
| Christian McCaffrey | RB | Rest | Did Not Practice |
| Eddy Pineiro | K | Hamstring | Did Not Practice |
| Trent Williams | OT | Rest | Did Not Practice |
| Tatum Bethune | LB | Ankle | Did Not Practice |
| Robert Beal | DL | Concussion | Did Not Practice |
| Luke Gifford | LB | Hip | Limited Participation |
| Dee Winters | LB | Knee | Full Participation |
| Ricky Pearsall | WR | Knee | Full Participation |
| Curtis Robinson | LB | Elbow | Full Participation |
đź“Š MATCHUP STATS & TRENDS
🔥 Panthers Key Players
-
Bryce Young: Coming off a 31.8-point fantasy game
Tetairoa McMillan: Rookie WR with 784 yards, 4 TDs; 130 yards, 2 TDs last game
Chuba Hubbard: Steady RB with 334 rushing yards this season
âš” 49ers Key Players
-
Christian McCaffrey: NFL leader in scrimmage yards (1,439); expected to dominate in receiving
Brock Purdy: Productive under HC Kyle Shanahan
Deebo Samuel & Brandon Aiyuk: Threats if Panthers focus too much on McCaffrey
🧠SCOUTING INSIGHT & STATS TO KNOW
-
Panthers rank 5th-worst in the NFL defending motion plays
49ers offense ranks 4th in motion usage at snap (41%)
Pass rush is weak on both sides: Panthers rank 31st, 49ers 32nd in pressure rate
Panthers improving vs run (17th) after finishing 32nd last season
49ers surprisingly rank just 27th in rushing yards/game
🎯 WHAT THE PANTHERS NEED TO WIN
-
Big plays from the Young–McMillan connection
Slow down McCaffrey, especially as a receiver
Win the turnover battle and hit explosive plays
🧢 NOTABLE GAME NOTES FOR FANS
-
Panthers debuting new uniform combo: Black helmet – White jersey – White pants – Black socks
First time facing former RB Christian McCaffrey since his trade in 2022
49ers HC Kyle Shanahan called WR McMillan “a future star”
Panthers are only half a game behind the NFC South lead (Buccaneers)
📣 #KeepPounding — DON’T MISS MONDAY NIGHT FOOTBALL!
Whether you’re cheering from Charlotte or halfway across the world, this is the Panthers’ chance to shock the NFL again. Save the time, grab your jersey, and get ready!
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