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WEEK12: 49ERS VS. PANTHERS

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🗓 Date & Kickoff Time:
Monday, November 24, 2025, at 8:15 PM ET

📍 Location:
Levi’s Stadium, Santa Clara, California

📺 TV & Streaming Options:

  • National broadcast on ESPN (with full Monday Night Football theme)

  • Stream available on NFL+, YouTube TV, Hulu Live, or the ESPN App

  • 🎟 How to Get Tickets & Price Range:

  • Prices range from $79 to $350+, depending on seat location and time of purchase


  • 📉 BETTING ODDS & SPREAD

    • Point Spread: 49ers -7

  • Over/Under: 49.5 points

  • Moneyline: 49ers -350 | Panthers +280

  • The Panthers enter as underdogs but have gone 6-4 outright and 7-3 ATS when underdogs this season.


    🩺 FINAL INJURY REPORT (as of Nov. 23)

    🔹 Carolina Panthers (7 players)

    PlayerPositionInjuryPractice Status
    Bryce YoungQBAnkleFull Participation
    Xavier LegetteWRHipFull Participation
    Tetairoa McMillanWRAnkleFull Participation
    Lathan RansomSHandFull Participation
    Tershawn WhartonDTKneeLimited Participation
    Trevin WallaceLBShoulderDid Not Practice
    Christian RozeboomLBHipDid Not Practice

    Panthers could be without both starting inside linebackers.

    🔺 San Francisco 49ers (10 players)

    PlayerPositionInjuryPractice Status
    Brock PurdyQBToeFull Participation
    Christian McCaffreyRBRestDid Not Practice
    Eddy PineiroKHamstringDid Not Practice
    Trent WilliamsOTRestDid Not Practice
    Tatum BethuneLBAnkleDid Not Practice
    Robert BealDLConcussionDid Not Practice
    Luke GiffordLBHipLimited Participation
    Dee WintersLBKneeFull Participation
    Ricky PearsallWRKneeFull Participation
    Curtis RobinsonLBElbowFull Participation

    📊 MATCHUP STATS & TRENDS

    🔥 Panthers Key Players

    • Bryce Young: Coming off a 31.8-point fantasy game

  • Tetairoa McMillan: Rookie WR with 784 yards, 4 TDs; 130 yards, 2 TDs last game

  • Chuba Hubbard: Steady RB with 334 rushing yards this season

  • 49ers Key Players

    • Christian McCaffrey: NFL leader in scrimmage yards (1,439); expected to dominate in receiving

  • Brock Purdy: Productive under HC Kyle Shanahan

  • Deebo Samuel & Brandon Aiyuk: Threats if Panthers focus too much on McCaffrey


  • 🧠 SCOUTING INSIGHT & STATS TO KNOW

    • Panthers rank 5th-worst in the NFL defending motion plays

  • 49ers offense ranks 4th in motion usage at snap (41%)

  • Pass rush is weak on both sides: Panthers rank 31st, 49ers 32nd in pressure rate

  • Panthers improving vs run (17th) after finishing 32nd last season

  • 49ers surprisingly rank just 27th in rushing yards/game


  • 🎯 WHAT THE PANTHERS NEED TO WIN

    • Big plays from the Young–McMillan connection

  • Slow down McCaffrey, especially as a receiver

  • Win the turnover battle and hit explosive plays


  • 🧢 NOTABLE GAME NOTES FOR FANS

    • Panthers debuting new uniform combo: Black helmet – White jersey – White pants – Black socks

  • First time facing former RB Christian McCaffrey since his trade in 2022

  • 49ers HC Kyle Shanahan called WR McMillan “a future star”

  • Panthers are only half a game behind the NFC South lead (Buccaneers)


  • 📣 #KeepPounding — DON’T MISS MONDAY NIGHT FOOTBALL!

    Whether you’re cheering from Charlotte or halfway across the world, this is the Panthers’ chance to shock the NFL again. Save the time, grab your jersey, and get ready!

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