WEEK 11 SHOWDOWN 49ERS VS CARDINALS
The San Francisco 49ers enter Week 11 of the 2025 NFL season under real pressure to win as they travel to face the Arizona Cardinals in a crucial NFC West showdown. Injuries, form and the playoff race are all hanging in the balance. This is a complete game brief for the 49ers Faithful before kickoff.
📍 General Game Information
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Matchup: San Francisco 49ers vs Arizona Cardinals
Week: NFL Week 11, 2025 season
Date: Sunday November 16, 2025
Kickoff time: 4:05 PM ET
Vietnam time: about 4:05 AM on November 17
Stadium: State Farm Stadium, Glendale, Arizona
Broadcast: FOX
The 49ers come in at 6 wins and 4 losses, still very much in the NFC West race. The Cardinals record is not clearly specified in the data, but they are in the mix in the division and this only increases the tension around this game.
📊 Betting Lines and Early Predictions
According to current odds and projections
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Spread: 49ers favored by about 3 points
Moneyline: 49ers around minus 159, Cardinals around plus 134
Over under: 48.5 points
Common score prediction: 49ers win around 25 to 20
Some models, however, slightly lean toward the Cardinals with a win probability around 53.34 percent when the spread sits at San Francisco minus 2.5. The main reason is the 49ers injury situation, especially on offense.
In other words, the 49ers Faithful cannot take this game lightly. This is exactly the kind of divisional matchup that can turn into a disaster if San Francisco starts slow or allows Arizona to capitalize on mistakes.
🩺 San Francisco 49ers Injury Report
Injury report based on Wednesday practice for Week 11
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Christian McCaffrey, RB, rest, DNP, probable
Trent Williams, OT, rest, DNP, probable
Alfred Collins, DL, hip, limited, questionable
Ricky Pearsall, WR, shoulder, limited, questionable but trending toward a return
Brock Purdy, QB, shoulder, limited, questionable but expected to return
Brandon Aiyuk, WR, knee, DNP, out long term
Key points
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The return of Brock Purdy is massive. It brings stability back to the offense after a stretch of turbulence caused by injuries.
Ricky Pearsall potentially returning helps offset part of the void left by Brandon Aiyuk.
Both McCaffrey and Trent Williams are listed as rest. That is mostly workload management, which is good news for fans who expect them to play.
Losing Aiyuk long term still hurts the passing game and limits the depth of the receiver group.
🚑 Arizona Cardinals Injury Report
The Cardinals are dealing with a very long and complicated injury list.
Some notable names
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Kelvin Beachum, OT, rest and groin, DNP, questionable
Baron Browning, LB, concussion, DNP, doubtful
Marvin Harrison Jr., WR, illness, DNP, likely out
Will Johnson, CB, back, DNP, questionable
Evan Brown, G, foot, DNP, questionable
Will Hernandez, G, knee, DNP, questionable
Zonovan Knight, RB, ankle, DNP, questionable
Max Melton, CB, concussion, DNP, doubtful
Walter Nolen II, DL, knee, DNP, questionable
BJ Ojulari, LB, knee, DNP, questionable
Zay Jones, WR, on IR, out
Simi Fehoko, WR, on IR, out
Mack Wilson, LB, ruled out
In total the Cardinals have around 16 players on the injury report, including multiple starters and key contributors on both offense and defense. This will likely force serious rotation at wide receiver, offensive line and in the front seven.
📋 San Francisco 49ers Projected Depth Chart
Offense (Base 11 personnel)
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QB: Brock Purdy
RB: Christian McCaffrey, backup Brian Robinson Jr.
WR1: Ricky Pearsall, backup Kendrick Bourne
TE: George Kittle, backup Luke Farrell
LT: Trent Williams
Other offensive line spots and additional receivers are not fully listed in the data, but it is clear that the offense will still be built around the core of Purdy, McCaffrey, Kittle and Pearsall in the absence of Aiyuk.
Defense (Base 4 2)
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DE: Nick Bosa, backup Yetur Gross Matos
DT: Javon Hargrave, backup Maliek Collins
LB: Fred Warner at the heart of the defense as the leader of the unit
CB: Charvarius Ward, backup Deommodore Lenoir
SS: Talanoa Hufanga
The 49ers defense still features stars who can flip a game in a single snap, especially Bosa up front and Warner in the middle.
📋 Arizona Cardinals Projected Depth Chart
Offense (Base 11 personnel, based on given data)
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QB: Kyler Murray
RB: James Conner
WR1: Marvin Harrison Jr. if healthy. If he is out, Arizona will need to shift to other receivers.
LT: Paris Johnson Jr., backup Kelvin Beachum
LG: Evan Brown, backup Jon Gaines II
C: Hjalte Froholdt, backup Jon Gaines II
RG: Will Hernandez, backup Isaiah Adams
The Cardinals offense is built primarily around Kyler Murray, James Conner and Marvin Harrison Jr. but both the offensive line and receiver group are being hit by injuries.
Defense (Base 3 4)
The data does not provide a full defensive depth chart, but it highlights that the front and linebacker group are heavily affected by injuries, including BJ Ojulari, Walter Nolen II and Mack Wilson. That could open opportunities for the 49ers run game and play action concepts.
🔥 Outlook For The 49ers Faithful
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The 49ers hold the edge in experience, roster quality and in a system that has already been proven.
The return of Brock Purdy plus the presence of Christian McCaffrey gives the offense enough firepower to control the tempo of the game.
The Cardinals can still be dangerous with Kyler Murray’s playmaking, but the sheer volume of injuries will make it hard for them to stay consistent across four quarters.
With a spread around 3 points and some models slightly leaning toward Arizona, San Francisco must play focused, limit turnovers and capitalize in the red zone.
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