WEEK 11 SHOWDOWN 49ERS VS CARDINALS

The San Francisco 49ers enter Week 11 of the 2025 NFL season under real pressure to win as they travel to face the Arizona Cardinals in a crucial NFC West showdown. Injuries, form and the playoff race are all hanging in the balance. This is a complete game brief for the 49ers Faithful before kickoff.

📍 General Game Information

• Matchup: San Francisco 49ers vs Arizona Cardinals

The 49ers come in at 6 wins and 4 losses, still very much in the NFC West race. The Cardinals record is not clearly specified in the data, but they are in the mix in the division and this only increases the tension around this game.

📊 Betting Lines and Early Predictions

According to current odds and projections

• Spread: 49ers favored by about 3 points

Some models, however, slightly lean toward the Cardinals with a win probability around 53.34 percent when the spread sits at San Francisco minus 2.5. The main reason is the 49ers injury situation, especially on offense.

In other words, the 49ers Faithful cannot take this game lightly. This is exactly the kind of divisional matchup that can turn into a disaster if San Francisco starts slow or allows Arizona to capitalize on mistakes.

🩺 San Francisco 49ers Injury Report

Injury report based on Wednesday practice for Week 11

• Christian McCaffrey, RB, rest, DNP, probable

Key points

• The return of Brock Purdy is massive. It brings stability back to the offense after a stretch of turbulence caused by injuries.

🚑 Arizona Cardinals Injury Report

The Cardinals are dealing with a very long and complicated injury list.

Some notable names

• Kelvin Beachum, OT, rest and groin, DNP, questionable

In total the Cardinals have around 16 players on the injury report, including multiple starters and key contributors on both offense and defense. This will likely force serious rotation at wide receiver, offensive line and in the front seven.

📋 San Francisco 49ers Projected Depth Chart

Offense (Base 11 personnel)

• QB: Brock Purdy

Other offensive line spots and additional receivers are not fully listed in the data, but it is clear that the offense will still be built around the core of Purdy, McCaffrey, Kittle and Pearsall in the absence of Aiyuk.

Defense (Base 4 2)

• DE: Nick Bosa, backup Yetur Gross Matos

The 49ers defense still features stars who can flip a game in a single snap, especially Bosa up front and Warner in the middle.

📋 Arizona Cardinals Projected Depth Chart

Offense (Base 11 personnel, based on given data)

• QB: Kyler Murray

The Cardinals offense is built primarily around Kyler Murray, James Conner and Marvin Harrison Jr. but both the offensive line and receiver group are being hit by injuries.

Defense (Base 3 4)

The data does not provide a full defensive depth chart, but it highlights that the front and linebacker group are heavily affected by injuries, including BJ Ojulari, Walter Nolen II and Mack Wilson. That could open opportunities for the 49ers run game and play action concepts.

🔥 Outlook For The 49ers Faithful

• The 49ers hold the edge in experience, roster quality and in a system that has already been proven.