The Buffalo Bills head to Pittsburgh in Week 13 of the 2025 NFL season for a huge AFC matchup against the Pittsburgh Steelers at Acrisure Stadium. With both teams fighting for playoff position, this is the kind of game that can swing an entire season, especially for Bills fans who know there is not much margin for error left.
Game Info: Time, Location, How to Watch
Matchup: Buffalo Bills vs Pittsburgh Steelers
Week: 13, NFL 2025
Date: Sunday, November 30, 2025
Kickoff time: 2:25 PM ET
Stadium: Acrisure Stadium, Pittsburgh, Pennsylvania
TV channel: CBS
This is one of the marquee late window games in Week 13, featuring a Super Bowl contender in Buffalo taking on one of the toughest home environments in the AFC.
Team Form Heading Into Week 13
Buffalo Bills
Record: 7 4
Considered a serious Super Bowl contender despite a frustrating recent loss to the Houston Texans where Josh Allen faced heavy pressure and was sacked multiple times.
The Bills offense remains one of the most explosive units in the league, ranking near the top in efficiency and scoring.
The main concern is the run defense, which has been vulnerable and can be exploited by physical ground games.
From a Bills fan perspective, this feels like a statement game. You want to see Allen and the offense bounce back, protect the football and prove they can dominate a playoff caliber defense on the road.
Pittsburgh Steelers
Record: 6 5
The Steelers are in the middle of the AFC playoff race and still very much alive for a wild card spot.
Their identity is built around a strong defense and pass rush, with T.J. Watt leading the charge.
Offensively, they lean on the run game and try to complement that with efficient passing, especially if Aaron Rodgers is on the field.
At home, under head coach Mike Tomlin, the Steelers are always physical, disciplined and tough to put away.
Key Injury Report
Buffalo Bills Injury Highlights
RT Spencer Brown (shoulder): Doubtful
WR Curtis Samuel (elbow): Questionable
TE Dalton Kincaid (hamstring): Questionable
DT Phidarian Mathis (shoulder): Questionable
If Brown is out or limited, that puts extra stress on the Bills offensive line against one of the best pass rushes in football. The status of Curtis Samuel and Dalton Kincaid will also be crucial for Allen in the passing game, especially on third downs and in the red zone.
Pittsburgh Steelers Injury Highlights
LT Broderick Jones (neck): Out
DT Derrick Harmon (knee): Out
QB Aaron Rodgers (left wrist): Listed as probable or optimistic to return, but still monitored
If Rodgers does play, the Steelers passing attack becomes far more dangerous. If he suffers a setback and cannot go, the Steelers offense likely shifts toward a more conservative game plan built around the run game and shorter throws.
Betting Odds and Market View
Current odds from major sportsbooks typically list:
Spread: Bills favored by about -3.5
Moneyline: Bills around -200, Steelers around +170
Over Under: Around 47.5 total points
The market clearly respects Buffalo as the better overall team, even on the road, but also respects Pittsburgh enough to keep the spread under a full touchdown.
Betting Trends
Bills have been inconsistent against the spread recently but usually perform well in matchups against the Steelers.
Steelers have been strong against the spread at home, especially as underdogs, and many of their games at Acrisure tend to lean toward the under in total points.
For neutral bettors, this feels like a classic battle between a more explosive favorite and a tough home underdog. For Bills fans, it is a must win type of spot.
Key Matchups To Watch
1. Josh Allen vs Steelers Pass Rush
This is the headline matchup.
T.J. Watt and the Steelers front generate constant pressure and create turnovers.
Josh Allen is at his best when he stays in control, uses his legs smartly, and avoids risky throws into tight coverage.
Protection on the edges, especially if Spencer Brown cannot play, will be critical.
If Allen can extend plays without forcing bad decisions, he can punish the Steelers secondary with deep shots and scramble plays.
2. Bills Run Defense vs Steelers Ground Game
The Bills run defense has had issues this season, giving up chunk yardage on the ground at times.
The Steelers will almost certainly test that weakness with a heavy dose of running plays and play action.
If Buffalo can slow down the run on early downs, they force Pittsburgh into obvious passing situations where their own pass rush and coverage can take over.
3. Red Zone Efficiency
The Bills offense sometimes stalls in the red zone, settling for field goals instead of finishing with touchdowns.
The Steelers defense is known for tightening up inside the 20 yard line, especially at home.
If Buffalo turns long drives into touchdowns instead of field goals, the scoreboard can tilt quickly in their favor.
X Factor For Bills Fans
From a Bills fan viewpoint, the emotional and mental response after the Texans game matters a lot. This is the game where you want to see:
Fewer self inflicted mistakes and penalties
Smarter decision making from Josh Allen
A more balanced attack with the run game helping to keep the Steelers honest
If the Bills look focused and disciplined, it will send a strong message that they are still firmly in the Super Bowl conversation.
Score Prediction: Bills vs Steelers Week 13
Taking into account injuries, current form and matchup advantages, a realistic prediction is:
Buffalo Bills 27, Pittsburgh Steelers 20
Reasons:
The Bills have the more dynamic and versatile offense.
Pittsburgh can keep it close for a while with defense and home field, but if Rodgers is limited or rusty, it will be difficult to keep pace on the scoreboard.
Buffalo should be highly motivated to clean up the issues from their last loss and reassert themselves as one of the top teams in the AFC.
For Bills fans, this is the kind of controlled road win you want to see: not necessarily a blowout, but a strong four quarter performance that restores confidence heading into the final stretch of the season.
