James Cook’s Struggles in the 2025 NFL Season: What’s Really Going Wrong for the Bills’ Star Running Back?

Buffalo Bills RB James Cook is facing a tough 2025 NFL season — from stacked defenses to limited playcalling and heavy workload. Here’s what’s holding him back and how he can bounce back after the bye week.

A Promising Star Now Under Pressure

After a breakout 2024 campaign where James Cook rushed for 1,122 yards and earned All-Pro honors, expectations were sky-high for the Buffalo Bills’ young running back heading into the 2025 NFL season.

But through the first six weeks, Cook hasn’t quite looked like the explosive force fans remember. The Bills’ offense — once one of the league’s most dynamic units — has struggled to find balance, leaving Cook fighting an uphill battle.

1. Defensive Adjustments: “Stack the Box” Strategy Hurting Production

Opposing defenses have caught on. Teams like the New England Patriots and Atlanta Falcons are stacking the box — crowding the line of scrimmage with extra defenders — to shut down Cook before he can break big runs.

This tactic worked perfectly in Week 6, when the Falcons limited Cook to 48 yards on 12 carries with no touchdowns in Buffalo’s frustrating loss. Without consistent deep threats from the Bills’ wide receivers, defenses feel comfortable daring Josh Allen to throw — while focusing their attention on Cook.

As analyst fans posted on X:

“Slow down James Cook, stack the box... Bills WRs haven’t proven they can win downfield.”

That single post, which earned nearly 400 likes, sums up Buffalo’s offensive woes perfectly.

2. Mental Strain and Pressure From Fans

The pressure is mounting. Bills fans, known for their passionate #BillsMafia spirit, haven’t been shy about voicing frustration. Two consecutive losses have only intensified the spotlight on Cook — a player once viewed as the spark plug for the offense.

Some insiders suggest Cook’s confidence has taken a hit due to the team’s inconsistent offensive rhythm. He’s been visibly frustrated on the sidelines, and with limited space to run, his trademark explosiveness has been harder to unleash.

Still, teammates and coaches insist his mindset remains strong. “He’s a competitor,” said one veteran lineman. “He knows we’ve got to block better — and he’s ready to respond.”

3. Fatigue and Minor Injury Concerns

While no major injury has been reported, Cook’s workload is beginning to show. As the Bills’ primary ball carrier, he’s faced increased contact, and analysts note signs of fatigue in his recent performances.

Head Coach Sean McDermott recently hinted that adjustments may come after the Week 7 bye, possibly involving Ty Johnson or Ray Davis to share the backfield load:

“We want to keep James fresh for the long haul. It’s a long season.”

The statement fueled speculation that Cook’s touches might be managed more carefully moving forward — especially with playoff hopes still alive.

4. Questionable Playcalling Limiting Cook’s Potential

Another major talking point among fans and media is offensive coordinator Joe Brady’s playcalling. Critics argue that the Bills’ offense has become predictable — especially in red zone situations, where Cook’s dynamic skill set has been underutilized.

Too many short-yardage runs up the middle have made Buffalo easy to defend, and the lack of creative screens or outside runs has frustrated fans.
If the Bills want to revive their offense, Brady must find ways to get Cook in space — where his vision and acceleration can turn simple plays into game-changing moments.

5. The Path Forward: Bye Week and a Chance to Reset

Fortunately for Cook and the Bills, the Week 7 bye comes at the perfect time. With rest, film review, and potential scheme tweaks, Buffalo can hit the reset button before their Week 8 clash with the Carolina Panthers.

The Panthers’ defense has struggled to stop the run this season, giving Cook a golden opportunity to bounce back and remind fans why he’s one of the most talented young running backs in the NFL.

If the Bills can also add a wide receiver via trade, as many fans hope, it could open up the field for Cook — reducing defensive pressure and giving him room to create those explosive plays that defined his 2024 season.

Don’t Count James Cook Out

Despite the slow start, James Cook’s story is far from over. The Bills’ offensive identity may be under scrutiny, but Cook remains one of the league’s most dangerous playmakers when used correctly.

With rest, adjustments, and a renewed sense of purpose, the second half of the 2025 NFL season could still belong to him. And if he regains his rhythm, the entire Bills Mafia will be right there cheering him on.

Grab your official James Cook jersey now and gear up for his comeback game.